Our aim is to develop a comprehensive, data-driven research program to better understand the cumulative neurological effects of high-performance aviation environments, particularly those involving repeated exposure to high G-forces and rapid acceleration events.

The initiative begins by establishing a detailed baseline for each participant through advanced neuroimaging, cognitive and neurological assessments, and exploratory biomarker and epigenetic profiling to better understand individual variability in stress response and recovery. These baseline measures enable longitudinal tracking of structural and functional changes over time. In parallel, we integrate high-resolution kinematic data collected from aircraft systems—including accelerometer-derived metrics capturing the magnitude, frequency, and duration of G-force exposure—into an individualized exposure profile for each flight. By combining engineering-based impact modeling with real-world operational data from events such as carrier catapult launches and arrested landings, we aim to quantify cumulative physical stress experienced by pilots. This research employs a cohort-based, longitudinal design, aligning biomechanical exposure data with clinical evaluations and advanced neuroradiological findings to identify potential correlations between repeated high-force exposure and neurological outcomes. Ultimately, this work seeks to establish a comprehensive framework for understanding risk, adaptation, and long-term brain health in high-performance aviation populations.